A huge game from the Premier League as Manchester United host Manchester City at Old Trafford.
Friday Night Football heads to Anfield as Liverpool host Huddersfield Town in the Premier League.
Tottenham Hotspur take on West Ham United at the Tottenham Hotspur Stadium in the Premier League. Spurs won the reverse fixture 1-0.
Sheffield United take on Ipswich Town at Bramall Lane in the Sky Bet Championship.
Brighton face Rafael Benitez's Newcastle at the Amex Stadium in the Premier League.
Norwich City meet Blackburn Rovers at Carrow Road in the Sky Bet Championship.
Two of the Sky Bet Championship's biggest sides meet as Leeds United host Aston Villa at Elland Road.
Burnley take on Manchester City at Turf Moor in the Premier League. These sides have already met twice this season - with City winning 5-0 on both occasions.
Manchester United take on Chelsea at Old Trafford in the Premier League. The reverse fixture ended 2-2 after a late equaliser for the Blues.